- 《英文msh詞典》Complexes,Ubiquitin-Protein Ligase
- [入口詞] Complexes,Ubiquitin-Protein Ligase
- [主題詞] Ubiquitin-Protein Ligase Complexes
- [英文釋義] Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES),conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES),and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
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